promethazine injection in pregnancy

Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients.Signs and symptoms of overdosage range from mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness and sudden death. Limited experience with dialysis indicates that it is not helpful.Promethazine hydrochloride injection can cause severe chemical irritation and Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.Do not use promethazine hydrochloride injection if solution has developed color or contains precipitate.To avoid the possibility of physical and/or chemical incompatibility, consult specialized literature before diluting with any injectable solution or combining with any other medication. As an adjunct to premedication, the suggested dose is 1.1 mg per kg of body weight in combination with an appropriately reduced dose of narcotic or barbiturate and the appropriate dose of an atropine-like drug (see Promethazine Hydrochloride Injection, USP is available as follows:To report SUSPECTED ADVERSE REACTIONS, contact West-Ward Pharmaceuticals Corp. at 1-877-845-0689, or the FDA at 1-800-FDA-1088 or PREMIERProRx® is a registered trademark of Premier Healthcare Alliance, L.P., used under license.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Irritation and damage can result from perivascular extravasation, unintentional intra-arterial injection, and intraneuronal or perineuronal infiltration. Note that any depressant effects of promethazine hydrochloride injection are not reversed by naloxone.Avoid analeptics, which may cause convulsions. There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS.Since recurrences of NMS have been reported with phenothiazines, the reintroduction of promethazine hydrochloride should be carefully considered.Promethazine hydrochloride injection contains sodium metabisulfite, a sulfite that may cause allergic-type reactions, including anaphylactic symptoms and life-threatening or less severe asthma episodes, in certain susceptible people. Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (such as before/after surgery, motion sickness). It is also used with other medication to treat severe allergic reactions (anaphylaxis) and reactions to blood products. Pediatric patients should be supervised to avoid potential harm in bike riding or in other hazardous activities. Promethazine hydrochloride injection should be used with caution in pediatric patients 2 years of age and older Antiemetics are not recommended for treatment of uncomplicated vomiting in pediatric patients, and their use should be limited to prolonged vomiting of known etiology. (See Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine hydrochloride injection. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.This product is light sensitive and should be inspected before use and discarded if either color or particulate is observed.Administration of promethazine has been associated with reported cholestatic jaundice.Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction.Promethazine hydrochloride injection should be used cautiously in persons with cardiovascular disease or impairment of liver function.Patients should be advised of the risk of respiratory depression, including potentially fatal respiratory depression in children less than 2 years of age (see Patients should be advised of the risk of severe tissue injury, including gangrene (see Promethazine hydrochloride injection may cause marked drowsiness or impair the mental or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery.

A paradoxical-type reaction has been reported in pediatric patients receiving single doses of 75 mg to 125 mg orally, characterized by hyperexcitability and nightmares.Atropine-like signs and symptoms-dry mouth; fixed, dilated pupils; flushing; etc., as well as gastrointestinal symptoms, may occur.Treatment of overdosage is essentially symptomatic and supportive. The warning label also recommends that promethazine should be administered with caution and at the lowest effective dose in children 2 years of age and older.

Promethazine is rapidly degraded by first-pass metabolism, resulting in limited bioavailability after oral or rectal administration.Promethazine is also effective for rescue treatment of established PONV and has been combined with 5-HTPromethazine received a black box warning from the FDA in 2004 indicating that the drug should not be used in children younger than 2 years of age because of potential fatal respiratory depression. Subcutaneous injection is contraindicated. encephalopathy or Reye's syndrome. (See Angioneurotic edema.

Consideration should be given to the discontinuation of promethazine hydrochloride injection and to the use of other drugs if these reactions occur. When animal models were given intraperitoneal doses, fetal mortality occurred. Respiratory Depression – Pediatrics Promethazine hydrochloride injection should not be used in pediatric patients less than 2 years of age because of the potential for fatal respiratory depression. When used for control of postoperative nausea and vomiting, the dosage of analgesics and barbiturates should be reduced accordingly (see Antiemetics should not be used in vomiting of unknown etiology in children and adolescents (see As an adjunct to preoperative or postoperative medication, 25 to 50 mg of promethazine hydrochloride injection in adults may be combined with appropriately reduced doses of analgesics and atropine-like drugs as desired.

Caution should be exercised when administering promethazine hydrochloride to pediatric patients 2 years of age or older. Bartfai 2008 , Diav-Citrin 2003 ). Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmias).The diagnostic evaluation of patients with this syndrome is complicated. Available for Android and iOS devices. Promethazine Injection can cause severe chemical irritation and damage to tissues regardless of the route of administration. It is also used with other medication to treat life-threatening allergic symptoms ( anaphylaxis ) and reactions to blood products.

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